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Jennifer MacNicol's PhD Defence
Three studies were conducted. In the first study, the influence of a simulated digest of a dietary supplement on the contractile response of gastric smooth muscle to acetylcholine (Ach) was evaluated. Porcine gastric smooth muscle was collected and established in organ baths with either a simulated digest of the supplement (FA), a blank digest with no supplement (BL), or a PBS control (CO). Increasing concentrations of Ach were added and contractile force measured using an isometric force transducer.